When “Healthy” Backfires: Why Your Supplements May Be Making Histamine Worse

Hello Beauty,

Have you ever done everything “right” when it comes to your health, only to feel worse? You are not alone. Many of my clients arrive confused and frustrated because the very supplements they thought were healing have left them more bloated, anxious, or symptomatic than before.

One of the most overlooked reasons lies in histamine intolerance and the enzyme called COMT—Catechol-O-Methyltransferase. Think of COMT as your body’s janitor. Its role is to clear out excess estrogen, as well as stress chemicals like dopamine and norepinephrine. 

When COMT is sluggish, stress piles up, estrogen builds up, and histamine—your body’s internal alarm—flares into symptoms such as headaches, insomnia, PMS, flushing, and anxiety.

Here is the sneaky part: even well-loved supplements can slow COMT and worsen histamine intolerance. Green tea and matcha, while wonderful for some, slow COMT. Quercetin blocks COMT in high doses. Curcumin and resveratrol, often praised for anti-inflammatory or anti-aging benefits, can do the same. 

Add estrogenic herbs such as red clover, licorice, or hops, and suddenly a “healthy” routine becomes a storm of symptoms.

Your Unique Blueprint

Before you toss your supplements in the bin, remember: we are all unique. What weakens one person’s system may strengthen another’s. I once developed a rash that would not heal and worsening allergy symptoms—only to realise my beloved green tea and supplement stack were driving my histamine higher. When I removed them, my body calmed within days.

This is why one-size-fits-all wellness advice so often fails. Your biochemistry, genetics, mineral status, and stress load weave together to create your personal health blueprint. What your friend thrives on may keep you awake at night.

Minerals: The Missing Spark

If there is one area where almost everyone struggles, it is minerals. They are the “spark plugs” of your metabolism. Without them, your engine will not run smoothly. Magnesium, zinc, copper, iron, and trace minerals regulate hormones, calm the nervous system, and assist in detoxification.

When deficient, the body is more likely to hold onto toxins, react with histamine flares, and spiral into brain fog, migraines, dehydration, or hormone swings. I often see symptoms ease dramatically when mineral balance is restored.

Why HTMA Testing Matters

This is why I use Hair Tissue Mineral Analysis (HTMA) in my practice. It is one of the most affordable and accurate ways to see what is happening at the cellular level. HTMA measures both essential minerals and toxic heavy metals, giving us insight into metabolism, energy, and detox capacity.

For someone struggling with histamine intolerance, HTMA can reveal if low magnesium or copper-zinc imbalances are putting pressure on COMT, or if hidden heavy metals are keeping the body in constant stress. Instead of guessing, we see the imbalances clearly and address them with precision.

Why One-to-One Works

This is where personalised support matters. Working one-to-one allows us to peel back the layers of what is truly happening in your body. Instead of following generic advice, we look at the root causes—whether sluggish COMT, mineral depletion, digestive weakness, or a nervous system stuck in overdrive.

The goal is never to take everything away but to restore balance. For histamine issues, that may mean adjusting supplements, easing COMT’s load, and adding nutrients like B2, B6, glycine, and taurine. When the foundations are stable, your system can finally exhale.

The Bigger Picture

The wellness world often urges us to do more—more supplements, more workouts, more intensity. But especially in midlife and beyond, healing often comes from refinement, not excess. It is about listening to the whispers of your body before they turn into screams, and honouring the truth that your path is not supposed to look like anyone else’s.

When we work this way, anxiety softens, energy steadies, sleep deepens, and brain fog clears. Healing is not about chasing perfection—it is about uncovering balance, layer by layer, until you feel at home in your body again.

A Gentle Call to Action

If your histamine feels out of control, or if you are stuck trying everything yet feeling worse, know this: there is another way. One-to-one coaching, paired with HTMA Testing helps us design a plan that honors your uniqueness.

Together, we strip away what is draining you and introduce what will nourish you, starting with your minerals. Because when minerals are balanced, everything else begins to align: hormones, energy, mood, even how you handle stress. You deserve to feel vibrant, clear-headed, and deeply supported in this next chapter of life.

Love and light,

Bliss